Hi,@HoWe Yu. Welcome to Microsoft Q&A.
If you want the text rendered by Glyphs and TextBlock to be consistent, you could refer to the following solution.
You need to cancel the additional settings for TextBlock: you need to delete <Window>'s TextOptions.TextFormattingMode="Display".
Related code
<Window
		...
        WindowStartupLocation="CenterScreen"      
        Background="#FFFFFF"
        TextOptions.TextRenderingMode="Aliased"
        Title="MainWindow" Height="720" Width="1280">
    <Grid x:Name="MainGrid">
        <Grid x:Name="PaperBox" Margin="0"></Grid>
        <Glyphs x:Name="MyGlyphs"  FontUri="C:\WINDOWS\Fonts\simsun.ttc" FontRenderingEmSize="13"  UnicodeString="Hello World!" Fill="Black" OriginX="100" OriginY="80" />
        <TextBlock x:Name="MyTextBlock" Text="Hello World!" FontFamily="NSimSun" FontSize="13" FontWeight="Normal" HorizontalAlignment="Left" VerticalAlignment="Top" Margin="100"></TextBlock>
    </Grid>
</Window>
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